The Marijuana Herald – Marijuana news and information
A study by the University of Iowa and the VA’s Center for the Prevention and Treatment of Visual Loss reports that a CBD–THC mix reduced migraine-like symptoms in an animal model.
The study, published in the journal Cephalalgia, tested a 100:1 ratio of cannabidiol (CBD) and tetrahydrocannabinol (THC) on mice, given intraperitoneally before centrally administering central calcitonin gene-related peptide (CGRP) to induce migraine-like symptoms. “Our findings show that pretreatment with 100:1 CBD:THC rescued light aversion caused by centrally administered CGRP in CD1 mice”, states the study. “Collectively, these results demonstrate that a combination of CBD and THC can alleviate light aversion and pain symptoms induced by a centrally-acting migraine trigger.”
In tests measuring light sensitivity, mice given the CBD–THC mix spent much more time in the lit area than those given only the migraine-triggering compound CGRP. This suggests the combination helped reduce light aversion, a common migraine symptom. The treatment also helped normalize other behaviors. For example, mice moved more between light and dark areas and were less inactive in darkness.
Researchers also used an automated “squint” test to measure pain by tracking how much the mice’s eyes narrowed. The CBD–THC mixture partly reduced this pain response. Overall, the results showed the biggest improvements in light sensitivity and movement, with smaller effects on facial pain behavior…