USF researchers develop tumor-targeting cancer treatment already saving pets: Human trials could be next

The Brief

  • Two USF medical engineering professors have created a treatment that delivers cancer drugs directly into tumor cells, avoiding widespread chemotherapy side effects.
  • Their technology is already shrinking tumors in animals and is entering a year-long melanoma trial in dogs.
  • FDA approval could open the door for human clinical trials as early as 2026.

TAMPA USF medical engineering professors Dr. Richard Heller and Dr. Mark Jaroszeski have spent more than three decades developing a targeted cancer-treatment technology that avoids traditional chemotherapy and surgery.

Big picture view:

Their technique uses pulsed electric fields combined with mild heat to temporarily open tumor cells. This allows therapeutic molecules, including drug therapy paired with immunotherapy, to enter the cells directly.

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