The retail landscape in the Palmetto State is seeing a mix of contraction and transformation in 2026. While South Carolina is enjoying rapid population growth which protects it from some national cuts, the state is not immune to the “fleet optimization” strategies of major chains. From the rebranding of a beloved regional coffee chain to the closure of key pharmacies in the capital, the shopping map is being redrawn.
Here is the definitive guide to the major store closures confirmed for South Carolina in 2026.
1. The Pharmacy Loss: Walgreens
The Headline: A busy Columbia corridor loses its drugstore. Location Closing: Columbia (Garners Ferry Road).
The most immediate confirmed closure for early 2026 is the Walgreens at 6500 Garners Ferry Road in Columbia.
- The Details: As part of the national chain’s plan to close 1,200 underperforming stores, this location is set to cease operations in late January 2026.
- The Impact: This is a significant blow to the area near the Dorn VA Medical Center. Residents and veterans who relied on this convenient stop will need to transfer prescriptions to the location further down Garners Ferry or to competitors, adding friction to the healthcare loop in the capital.
2. The Coffee Rebrand: Clutch Coffee Bar
The Headline: A regional favorite disappears to make way for a giant. Locations: Statewide (All 17 NC/SC locations)…