This article references population data and demographic research from the U.S. Census Bureau, reporting from St. Louis Public Radio, and analysis from urban policy organizations including Detroit Future City and the Economy League of Greater Philadelphia.
4 Major U.S. Cities That Have Lost Large Numbers of Residents
For generations, American cities represented opportunity, innovation, and economic growth. Large metropolitan areas attracted millions of people looking for jobs, culture, and better lives.
In recent years, however, some once-thriving cities have experienced significant population losses and economic challenges.
According to the U.S. Census Bureau, population growth in the United States has slowed considerably. The agency’s Vintage 2025 estimates show the U.S. population increased by about 1.8 million people, or roughly 0.5%, between July 1, 2024, and July 1, 2025.…