Ohio State is favored by 21.5 points over visiting Iowa this Saturday (3:30 p.m. ET; CBS). The No. 3 Buckeyes (4-0, 1-0 Big Ten) are coming off of a 38-7 win at Michigan State where OSU covered the 23.5-point spread. The Hawkeyes (3-1, 1-0) were off this past weekend, but were impressive the previous week when they knocked off Minnesota 31-14.