- Greenville, South Carolina, remains the state’s “rattiest city” according to a 2026 Orkin report.
- The city dropped 10 spots to number 40 on the national list of most rat-infested cities.
- Orkin’s list is based on the number of new rodent service calls to residences over a 12-month period.
An Upstate South Carolina city continues to hold the title of “rattiest city” in the state and sits among the top 50 rat-infested cities in the U.S.
Greenville continues to hold a place in Orkin’s “Rattiest Cities” list in 2026, but it has dropped a number of spots since 2025. Orkin assesses the “rattiest cities” by tracking new rodent services in owner-occupied residences during 12 months between Aug. 9, 2025, and Aug. 9, 2026.
“There’s no single type of city or climate that’s immune to rodent pressure,” said Dr. Shannon Sked, National Technical Director at Orkin. “Rats and mice are highly adaptable and can thrive in communities across the country wherever they can find food, water and shelter.”…