One Indiana city made the list of the cities in America most infested with rats. Care to guess which one?. Orkin just released its list of the Top 50 Rattiest Cities in the U.S. They ranked metro regions by the number of new rodent treatments performed from September 1, 2023, to August 31, 2024. This ranking includes both residential and commercial pest control treatments. According to Orkin, Mice and rats are a serious concern to the millions of homeowners who deal with infestations each fall. As the weather cools, rodents seek warm shelter and food sources. They enter and invade your piping and even chew through your walls. Many times, rats and mice will chew through wiring in your home, which causes an increased risk of fires. So not only are they disgusting critters, but they could cause quite a bit of damage.