Southern Michigan is the most populated region of the state, so it’s no surprise that the most interstate highways crisscross this portion of the state. Interstates 94 and 96 run west to east and I-69 and I-75 are north-south (until I-69 hits Lansing and changes orientation). Add in I-196 up the lakeshore and you will find nearly all counties in the southern portion of the state have interstate highways.