LOUISVILLE, Ky. – The Louisville football program started their 2025 season with a blowout over in-state FCS foe Eastern Kentucky, and oddsmakers are liking them to carry that momentum into their next game against James Madison.
According to DraftKings, the Cardinals have opened up as a 16.5-point favorite to the visiting Dukes. The over/under has not yet been set.
Louisville got off to an explosive start to their 2025 season, coming out on top of Eastern Kentucky with a resounding 51-17 victory. The Cardinals put 542 total yards of offense, including 373 in the first half., while holding the Colonels to just 150 yards total. RB Isaac Brown had 126 yards and two touchdowns on the ground, WR Caullin Lacy had a 93-yard punt return touchdown, and DE Clev Lubin had a pair of sacks…