Scientists at UC San Diego, the Salk Institute, and the University of North Carolina have drawn up a detailed genetic atlas that shows how CD8 “killer” T cells decide whether the keep fighting tumors or slide into exhaustion. Using that map, the team flagged two transcription factors that, when switched off, allow exhausted T cells to regain their tumor-killing power while still preserving long-term immune memory. The work, published this week in Nature, points to fresh ways to design CAR T and adoptive cell therapies.
How the atlas maps T cell fate
The study, published in Nature today, built a multi omics atlas that integrates transcriptional and epigenetic data across nine CD8+ T cell states, according to Nature. Using a computational…..