209 West Saint Julian St. Please enjoy our American Prohibition Museum of Savannah Georgia Review!. The American Prohibition Museum, located in Savannah, Georgia, is the first and only museum in the United States dedicated to the history of Prohibition. This fascinating museum delves into the era of the 18th Amendment, when the production and sale of alcohol were outlawed in the United States from 1920 to 1933. Through interactive exhibits, artifacts, and immersive displays, visitors can experience the social and cultural impact of this unfortunate period.