Louisiana has over 304 recognized cities, towns, and villages throughout the state’s 64 parishes, which of them are the biggest?. Analyzing the most recent population data from the 2020 U.S. Census we have determined which cities in Louisiana have the largest populations and listed the biggest 10 here. If you were hoping to find which cities were biggest by land area then you’re outta luck here, but we can tell you that New Orleans is the biggest at 169.49 square miles of land to the city’s name.