Bed bugs are a persistent pest problem across the United States, and Indiana has become a hotspot for these notorious insects. Multiple national studies have ranked Indiana cities as among the worst in the country for bed bug infestations, with residents in several cities facing ongoing challenges.
Indianapolis: The State’s Most Infested City
Indianapolis ranks as Indiana’s most bed bug-infested city, holding the 31st worst spot nationally out of 500 cities. In 2025’s Orkin ranking, Indianapolis climbed to 5th worst in the country, making it the only Indiana city in the top 10.
The city’s high infestation risk ranking (21st nationally) and urban density contribute to the problem. Indianapolis has consistently appeared on Orkin’s top bed bug cities list for multiple years.
Fort Wayne: Second-Largest City, Third-Best Problem
Fort Wayne, Indiana’s second-largest city, ranks 169th nationally out of 500 cities. In 2025, it improved to 33rd worst in the country on Orkin’s list.
The city’s infestation risk ranking of 184 combined with moderate pest control availability (174th nationally) creates ongoing challenges for residents.
South Bend: Fighting the Fighting Irish’s Bed Bugs
South Bend ranks 225th nationally overall but improved to 27th worst in the U.S. in 2025. The city has the 336th highest infestation risk but benefits from strong pest control availability (111th nationally)…