The Michigan State Spartans visit the No. 3 Notre Dame Fighting Irish on Saturday, Sept. 19, 2026 at 7:30 p.m. ET from Notre Dame Stadium in South Bend, Indiana. Both teams enter at 2-0, with Michigan State coming off wins over Toledo (30-20) and Eastern Michigan (35-7) and Notre Dame off wins over Wisconsin (41-13) and Rice (52-0).
Notre Dame’s offense has set an early tone. CJ Carr has thrown for 492 yards and six touchdowns without an interception, and the Fighting Irish are allowing just 6.5 points per game.
Michigan State has balanced the ball through Alessio Milivojevic and Cam Edwards. Milivojevic has passed for 417 yards and three touchdowns without an interception, and Edwards has run for 250 yards and three scores.
The Fighting Irish are 29.5-point favorites over the Spartans at consensus pregame odds, with a total of 52.5 and a moneyline of -6667 for Notre Dame and +1917 for Michigan State…