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The Midwest beer scene is impressive, and if you want to get a taste of some of that excellence, plan a visit to St. Louis, Missouri. It ranked No. 2 in the Best Beer City category in USA Today’s 10Best Readers’ Choice Awards for 2026, and it’s easy to see why. From small craft producers to the largest brewery in the U.S., the St. Louis metro area is home to more than 70 breweries. Beyond beer, St. Louis offers plenty to do day and night, with parks, pubs, parties, and more.
Major beer brand Anheuser-Busch is headquartered in St. Louis’ historic Soulard neighborhood. The company traces its roots to the Bavarian Brewery, which Eberhard Anheuser took over in the 19th century. In 1876, the company introduced what would become its flagship beer, Budweiser, an American-style lager. After a brief pivot to other products during Prohibition, the brewery and brand continued to grow. Today, several Anheuser-Busch beers rank among the most searched in the country, according to Innerbody’s analysis of Google Trends data…