The Oregon Ducks vs. USC Trojans is the biggest early-season matchup for both teams as both Oregon and USC enter the fall with Big Ten title hopes and College Football Playoff Dreams, but early betting odds have highlighted the small gap that still exists between the programs.
According to DraftKings Sportsbook, Oregon is favored by 5.5 points over USC despite the Trojans having home-field advantage on Sept. 26 when the Ducks travel to Southern California to play in the Los Angeles Memorial Coliseum.
The two programs squared off in 2025, and Oregon effectively ended USC’s CFP chances by handing the Trojans a loss inside of Autzen Stadium.
Heading into 2026, both USC quarterback Jayden Maiava and Oregon quarterback Dante Moore return to lead high-powered offenses. As a result, whichever defense can come up with more stops will likely lead their team to victory…